4.3 Article

Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity

期刊

ONCOTARGET
卷 8, 期 23, 页码 37342-37354

出版社

IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16954

关键词

calprotectin; S100A8/A9; food hypersensitivity; IgE; animal experiment

资金

  1. Shanghai Municipal Commission of Health and Family Planning [201640297]
  2. Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition [11DZ2260500]
  3. National Natural Science Foundation of China [81172686, 81302446]

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Calprotectin, also known as S100A8/A9, has been linked to gut inflammation caused by IgE-mediated food hypersensitivities, but the pathophysiologic abnormalities it causes remain to be determined. We created a mild food hypersensitivity model through oral gavage of ovalbumin in Norway brown rats without using immune adjuvant. Changes in the levels of calprotectin and inflammation-associated cytokines were then observed over time. We found that fecal calprotectin as well as jejunal and liver TLR4, TNF-alpha, NF-kappa B, IL-1 beta, and IL-6 were upregulated in hypersensitive rats. Additionally, the influence of calprotectin on CD4(+) T and dendritic cells was observed by co-culturing CD4(+) T cells with dendritic cells, which revealed a shift toward increased Th2 T cells in calprotectin-treated cultures. These results suggest that calprotectin, along with other inflammatory factors, promotes the inflammation seen in mild food allergy.

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