期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 27, 页码 4532-4538出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201500737
关键词
Sol-gel processes; Surfactants; Nanofibers; Electrospinning; Drug delivery
资金
- National Nature Science Foundation of China [51232006]
- Qianjiang Talent Program of Zhejiang Province [2013R10037]
- Nature Science Foundation of Zhejiang Province [LY15E020005]
- National Institutes of Health [EB015190]
- National Science Foundation [CMMI-1234957]
Calcium titanate (CaTiO3) nanofibers with controlled microstructure were fabricated by a combination of sol-gel and electrospinning approaches. The fiber morphology has been found to rely significantly on the precursor composition. Altering the volume ratio of ethanol to acetic acid from 3.5 to 1.25 enables the morphology of the CaTiO3 nanofibers to be transformed from fibers with a circular cross section to curved ribbon-like structures. Ibuprofen (IBU) was used as a model drug to investigate the drug-loading capacity and drug-release profile of the nanofibers. It was found that the BET surface area and the pore volume decrease markedly with the utilization of F127 surfactant. The nanofibers synthesized without F127 surfactant present the highest drug-loading capacity and the most sustained release kinetics. This study suggests that calcium titanate nanofibers can offer a promising platform for localized drug delivery.
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