期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 27, 页码 7967-7970出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201700513
关键词
Bronsted acids; Friedel-Crafts reactions; indolizines; Michael addition; phosphoric acids
资金
- FAPESP-Brazil [2014/02062-6, 2013/10449-5, 2013/07600-3]
- CNPq-Brazil [307840/2014-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/07600-3] Funding Source: FAPESP
A catalytic enantioselective conjugate addition of indolizines to enones is described. The chiral phosphoric acid (S)-TRIP activates alpha,beta-unsaturated ketones, thereby promoting an enantioface-differentiating attack by indolizines. Using this reaction, several alkylated indolizines were synthesized in good yields and with enantiomeric ratios of up to 98:2.
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