期刊
ONCOTARGET
卷 8, 期 20, 页码 33652-33657出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16856
关键词
chronic stress; cytokines; chemokines; social restriction; human
资金
- Science Philosophy Betterment Society
- National Natural Science Foundation of China [81501164, 81611130224]
- Jiangsu Provincial Natural Science Foundation [BK20140917]
Chronic stress triggers rigorous psychological and physiological changes, including immunological system adaptations. However, the effects of long-term social restriction on human immune system have not been investigated. The present study is to investigate the effect of chronic stress on immune changes in human blood, with the stress stimuli controlled. 10 male volunteers were group isolated from the modern society in a 50-meter-square room for 150 days, with enriched nutrition and good living conditions provided. Serum examination of immune system markers demonstrated numerous changes in different aspects of the immune functions. The changes were observed as early as 30 days and could last for another 150 days after the termination of the restriction period (300 days' time point). The results strongly argued for the adaptation of immunological system under chronic social restriction stress in adult human, preceding a clear change in psychological conditions. The changes of these immune system factors could as well act as the serum biomarkers in clinical early-diagnosis of stress-related disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据