期刊
CURRENT OPINION IN IMMUNOLOGY
卷 44, 期 -, 页码 26-33出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2016.10.003
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类别
资金
- National Institutes of Health [AI072429, AI105184, AI063302]
- Lupus Research Institute
- Burroughs Wellcome Fund
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition.
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