期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 25, 页码 21124-21132出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b04360
关键词
iron phthalocyanine; human serum albumin; photoacoustic imaging; photothermal therapy; cancer
资金
- National Natural Science Foundation of China [51572269, 51472252]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB17030400]
Exploring novel and versatile nanomaterials for the construction of personalized multifunctional phototheranostics with significant potentials in bioimaging-guided tumor phototherapies has attracted considerable attention. Herein, the phototheranostic agent human serum albumin-iron (II) phthalocyanine FePc nanoparticles (HSA-FePc NPs) were fabricated for photoacoustic (PA) imaging-guided photothermal therapy (PTT) of cancer in vivo. The prepared HSA-FePc NPs exhibited high stability, efficient NIR absorption, good capability and stability of photothermal behavior with a high photothermal conversion efficiency of similar to 44.4%, high contrast and spatial resolution of PA imaging, efficient cancer therapy, and low long-term toxicity. This potent multifunctional phototheranostic is, therefore, very promising and favorable for effective, precise, and safe antitumor treatment in clinical application.
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