期刊
ONCOTARGET
卷 9, 期 2, 页码 2367-2383出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.23414
关键词
5-fluorouracil; miR-15a; colorectal cancer; chemoresistance; modified miRNA
资金
- National Institute of Health/National Cancer Institute [R01CA15501904, R01CA19709801]
- NATIONAL CANCER INSTITUTE [R01CA197098] Funding Source: NIH RePORTER
Despite advances in colon cancer treatments, resistance and recurrence remain a significant challenge in treating patients. Novel therapeutic strategies are in urgent need to overcome resistance and improve patient outcomes. MicroRNA based therapeutics have potential to help combat resistance. In this study, we have shown that low miR-15a expression correlates with poor patient prognosis. We have demonstrated the therapeutic potential of miR-15a in colon cancer. miR-15a inhibits several important genes (BCL2, BMI1, YAP1 and DCLK1), decreasing cancer progression and resistance. Additionally, by replacing uracil in miR-15a with 5-fluorouracil, we created a novel miR-15a mimic with enhanced therapeutic potential. This mimic maintains target specificity and is more potent than unmodified miR-15a in vitro and inhibits colon tumor metastasis in vivo. This mimic has great potential for therapeutic development for treating colon cancer patients. This novel modification has potential to advance the development of other microRNA based therapeutics beyond miR-15a.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据