期刊
CHEMICAL REVIEWS
卷 117, 期 12, 页码 7762-7810出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00020
关键词
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资金
- National Natural Science Foundation of China [81502978, 81673352]
- Bio-Pharmaceutical Project of Science and Technology of Shanghai [15431901700]
- Shanghai ChenGuang project [16CG42]
- National Cancer Institute, National Institutes of Health (USA) [R01CA193278]
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein,, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
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