期刊
ONCOTARGET
卷 9, 期 2, 页码 2895-2901出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.22814
关键词
interleukin-36; inflammatory disease; psoriasis; arthritis
资金
- Shenzhen Science and Technology Research Foundation [JCYJ20160422154407256]
- Shenzhen Health Plan Committee Research Foundation [201601014]
- Sanming project of medicine in Shenzhen
- group of Rheumatology and Immunology [SYJY201704, SYJY201705]
- National Basic Research Program of China (973 program) [2014CB541904]
- National Natural Science Foundation of China [81373195, 81771761, 91442116]
The inteleukin-36 (IL-36) cytokines include IL-36 alpha, IL-36 beta, IL-36 gamma and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a brief review on the activation of IL-36 family cytokines and their involvement in autoimmunity and inflammatory diseases, which will provide further insights in understanding the functions of IL-36 family cytokines in the pathophysiology of autoimmunity and inflammatory diseases.
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