期刊
ONCOTARGET
卷 8, 期 61, 页码 103815-103827出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.21793
关键词
dihydroartemisinin; EMT; Akt; Snail
资金
- National Natural Science Funds of China [81402973, 81572838]
- Tianjin science and technology innovation system and the condition of platform construction plan [14TXSYJC00572]
- National Biomedical Special Project of International Innovation Park [13ZCZDSY02600, 13ZCZDSY03300]
- Tianjin Natural Science and Technology Fund [15JCYBJC26400]
- Foundation for the Author of National Excellent Doctoral Dissertation of China [201482]
- Tianjin Research Program of Application Foundation and Advanced Technology [13JCYBJC39600]
- Tianjin Science and Technology Project [15PTGCCX00140, 2017ZX09306007]
Artemisinin and its derivatives exhibit a high activity against a range of cancer cell types both in vitro and in vivo. In clinical practice, platinum-based anti-cancer chemotherapy is widely used to treat tumors. However, a large proportion of patients receiving these treatments will relapse because of metastasis and drug resistance. The purpose of this study is to explore the combinational anti-metastatic effect of platinum-based drugs and dihydroartemisinin (DHA). Both DDP and oxaliplatin (OXA) at low doses could induce epithelial-mesenchymal transition (EMT) in HCC. Meanwhile, co-administration of DHA could enhance DDP and OXA chemosensitivity in HCC and reverse drug resistance. DHA reversed the morphological changes induced by DDP or OXA and reversed the changes in EMT biomarkers induced by DDP and OXA in HCC in vitro and in vivo via AKT-Snail signaling. DHA significantly increased platinum-based drug sensitivity and suppressed EMT induced by platinum-based drugs via AKT-Snail signaling in HCC. DHA is expected to become the new adjuvant for chemotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据