期刊
ONCOTARGET
卷 8, 期 62, 页码 106132-106142出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.22190
关键词
melanoma; immune system; immunogenicity; immunoediting; immune escape
资金
- Italian Association for Cancer Research (AIRC) [17536]
- Apulia Region (Oncogenomic Project)
- Jonico-Salentino Project
Melanoma is one of the most immunogenic tumors and its relationship with host immune system is currently under investigation. Many immunomodulatory mechanisms, favoring melanomagenesis and progression, have been described to interfere with the disablement of melanoma recognition and attack by immune cells resulting in immune resistance and immunosuppression. This knowledge produced therapeutic advantages, such as immunotherapy, aiming to overcome the immune evasion. Here, we review the current advances in cancer immunoediting and focus on melanoma immunology, which involves a dynamic interplay between melanoma and immune system, as well as on effects of targeted therapies on tumor microenvironment for combination strategies.
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