期刊
ONCOTARGET
卷 8, 期 49, 页码 86410-86422出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.21195
关键词
HOTAIR; miR-125; miR-143; ESCC; HK2
资金
- National Natural Science Foundation of China (NSFC) [81372656, 81672423]
- Jiangsu Natural Science Foundation [BK20151292]
- Jiangsu Provinceal Medical Innovation Team of the Project of Invigorating Health Care through Science, Technology and Educationg, 333 Project Foundation of Jiangsu Province [BRA2014355]
- Six talent peaks project in Jiangsu Province [WSN084]
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The competitive endogenous RNA (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy.
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