期刊
ONCOTARGET
卷 8, 期 54, 页码 92966-92977出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.21715
关键词
cancer/testis; cancer antigens; biomarkers; prognosis
资金
- CAPES [23038.004629/2014-19]
- Ludwig Institute for Cancer Research
- Institute of Bioinformatics and Biotechnology
Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genomewide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据