期刊
ONCOTARGET
卷 8, 期 50, 页码 88232-88243出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.21088
关键词
cortactin; Arp2/3 complex; cancer cell; cell migration; cell invasion
资金
- Shan Dong Science Foundation
- Shan Dong Science and technology Foundation [BS2011SW049, J13LE05]
Cortactin, a substrate of sarcoma (Src) kinases, is an actin-binding protein that is involved in cytoskeletal regulation, and is frequently overexpressed in cancer cells. Binding to the actin related protein 2/3 (Arp2/3) complex stimulates cortactin activity, which promotes F-actin nucleation and assembly. Cortactin promotes cancer cell migration and invasion, and plays a pivotal role in invadopodia formation and extra cellular matrix degradation. Overexpression of cortactin, by amplification of the chromosomal band 11q13, increases tumor aggressiveness. In this review, we report on the current knowledge and potential mechanisms of action of cortactin as a critical mediator of cancer cell migration and invasion.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据