期刊
ONCOTARGET
卷 8, 期 47, 页码 81776-81793出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20819
关键词
pancreatic cancer; ONC201; ONC212; AG1024; IGF1-R
资金
- NIH [R01 CA173453]
- American Cancer Society
- Wellcome Trust [102696]
Pancreatic cancer is chemo-resistant and metastasizes early with an overall five-year survival of similar to 8.2%. First-in-class imipridone ONC201 is a small molecule in clinical trials with anti-cancer activity. ONC212, a fluorinated-ONC201 analogue, shows preclinical efficacy in melanoma and hepatocellular-cancer models. We investigated efficacy of ONC201 and ONC212 against pancreatic cancer cell lines (N = 16 including 9 PDX-cell lines). We demonstrate ONC212 efficacy in 4 in-vivo models including ONC201-resistant tumors. ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, we found an active combination of ONC212 with inhibitor AG1024, including in vivo. We show a rationale for targeting pancreatic cancer using ONC212 combined with targeting the unfolded-protein response and ER chaperones such as GRP78/BIP. Our results lay the foundation to test imipridones, anti-cancer agents, in pancreatic cancer, that is refractory to most drugs.
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