期刊
ONCOTARGET
卷 8, 期 52, 页码 89811-89823出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20688
关键词
circulating microRNAs; ovarian cancer; exosomes; biomarkers; liquid biopsy
资金
- Japan Science and Technology Agency (JST) through the Center of Open Innovation Network for Smart Health (COINS)
- Basic Science and Platform Technology Program for Innovative Biological Medicine
- Project for Development of Innovative Research on Cancer Therapeutics (P-Direct)
- National Cancer Center Research and Development Fund [26-A-3]
- Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [17H04338, 16H05472, 16K15704] Funding Source: KAKEN
Ovarian cancer is the leading cause of gynecologic cancer mortality, due to the difficulty of early detection. Current screening methods lack sufficient accuracy, and it is still challenging to propose a new early detection method that improves patient outcomes with less-invasiveness. Although many studies have suggested the utility of circulating microRNAs in cancer detection, their potential for early detection remains elusive. Here, we develop novel predictive models using a combination of 8 circulating serum miRNAs. This method was able to successfully distinguish ovarian cancer patients from healthy controls (area under the curve, 0.97; sensitivity, 0.92; and specificity, 0.91) and early-stage ovarian cancer from patients with benign tumors (0.91, 0.86 and 0.83, respectively). This method also enables subtype classification in 4 types of epithelial ovarian cancer. Furthermore, it is found that most of the 8 miRNAs were packaged in extracellular vesicles, including exosomes, derived from ovarian cancer cells, and they were circulating in murine blood stream. The circulating miRNAs described in this study may serve as biomarkers for ovarian cancer patients. Early detection and subtype determination prior to surgery are crucial for clinicians to design an effective treatment strategy for each patient, as is the goal of precision medicine.
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