期刊
ONCOTARGET
卷 8, 期 44, 页码 77710-77721出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20772
关键词
a disintegrin and metalloprotease 12; knee osteoarthritis; polymorphism; risk; meta-analysis
资金
- National Natural and Science Foundation [81501874]
- Jiangsu Province Health and Family Planning Commission Foundation [Q201511, QNRC2016139]
- Project of Invigorating Health Care through Science, Technology and Education (Jiangsu Provincial Medical Youth Talent)
- Changzhou High-level Medical Talents Training Project [2016CZBJ029]
Previous studies that evaluated the association between a disintegrin and metalloprotease 12 (ADAM12) gene polymorphisms and knee osteoarthritis (KOA) have given controversial and indefinite results. Therefore, we performed a meta-analysis to confirm this correlation. We searched the PubMed, Embase, and SinoMed databases for all papers published up to April 11, 2017. Overall, five different studies, totaling 2,353 cases and 3,668 controls, were retrieved on the basis of the search criteria for KOA susceptibility related to four polymorphisms (rs3740199, rs1278279, rs1871054, and rs1044122) in the ADAM12 gene. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed using Egger's and Begg's tests. The rs3740199 G/C polymorphism was found to be associated with increased KOA risk in men (e.g., CG versus GG: OR = 1.44, 95% CI = 1.02-2.04, P = 0.040), but not in the overall analysis and in analyses of other subgroups. Significantly increased associations were also found for the rs1871054 polymorphism (e.g., C versus T allele: OR = 1.85, 95% CI = 1.49-2.30, P < 0.001). However, there were no associations for the rs1278279 and rs1044122 polymorphisms. Furthermore, no obvious evidence of publication bias was detected. Our study indicated that the rs1871054 polymorphism of ADAM12 was significantly associated with increased KOA risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据