期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 178, 期 1, 页码 94-98出版社
WILEY
DOI: 10.1111/bjh.14643
关键词
multiple myeloma; prognosis; telomere; genome instability
类别
资金
- Bloodwise [13033, 06002, 13044]
- Leukaemia Research Appeal for Wales
- Cancer Research UK [C17199/A18246]
- Cancer Research UK [18246, 15954] Funding Source: researchfish
The variable clinical outcomes of Multiple Myeloma (MM) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high-resolution telomere length analysis as a prognostic marker in MM. Cohort stratification, using a previously determined length threshold for telomere dysfunction, revealed that patients with short telomeres had a significantly shorter overall survival (P < 0.0001; HR = 3.4). Multivariate modelling using forward selection identified International Staging System (ISS) stage as the most important prognostic factor, followed by age and telomere length. Importantly, each ISS prognostic subset could be further risk-stratified according to telomere length, supporting the inclusion of this parameter as a refinement of the ISS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据