期刊
ONCOTARGET
卷 8, 期 18, 页码 29914-29924出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15530
关键词
MicroRNA; MDM4; p53; cancer; cell cycle
资金
- NHMRC [1048134, 1083961]
- Young Investigator Award from the Prostate Cancer Foundation (the Foundation 14 award)
- National Health and Medical Research Council of Australia [1083961] Funding Source: NHMRC
p53, a transcription factor that participates in multiple cellular functions, is considered the most important tumor suppressor. Previous evidence suggests that post-transcriptional deregulation of p53 by microRNAs contributes to tumorigenesis, tumor progression and therapeutic resistance. In the present study, we found that the microRNA miR-766 was aberrantly expressed in breast cancer, and that overexpression of miR-766 caused accumulation of wild-type p53 protein in multiple cancer cell lines. Supporting its role in the p53 signalling pathway, miR-766 decreased cell proliferation and colony formation in several cancer cell lines, and cell cycle analyses revealed that miR-766 causes G2 arrest. At a mechanistic level, we demonstrate that miR-766 enhances p53 signalling by directly targeting MDM4, an oncogene and negative regulator of p53. Analysis of clinical genomic data from multiple cancer types supports the relevance of miR-766 in p53 signalling. Collectively, our study demonstrates that miR-766 can function as a novel tumor suppressor by enhancing p53 signalling.
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