期刊
DEVELOPMENT
卷 144, 期 13, 页码 2445-2455出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.152975
关键词
Drosophila; GDF11; Myoglianin; Myostatin; Muscle size; Synapse
资金
- Wellcome Trust
- Max Planck Society
- Biotechnology and Biological Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/I018921/1] Funding Source: researchfish
- Medical Research Council [MC_U132681855, MR/N025644/1] Funding Source: researchfish
- BBSRC [BB/I018921/1] Funding Source: UKRI
- MRC [MC_U132681855, MR/N025644/1] Funding Source: UKRI
Growth factors of the TGF beta superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of myostatin and its cognate receptors in other tissues, including brain and peripheral nerves, suggests a potential wider biological role. Here, we show that Myoglianin (MYO), the Drosophila homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures, suggesting an effect on synaptogenesis beyond neuromuscular junctions. We also show that MYO acts in vivo to inhibit synaptic transmission between neurons in the escape response neural circuit of adult flies. Thus, these anti-myogenic proteins act as important inhibitors of synapse function and neuronal growth.
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