期刊
ENEURO
卷 4, 期 4, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0246-17.2017
关键词
dorsal root ganglia; glucocorticoid receptor; plasticity; stress
资金
- National Institute of Neurological Disorders and Stroke Grants [R01 NS083942, R01 HD057632]
Stress and glucocorticoid (GC) release are common behavioral and hormonal responses to injury or disease. In the brain, stress/GCs can alter neuron structure and function leading to cognitive impairment. Stress and GCs also exacerbate pain, but whether a corresponding change occurs in structural plasticity of sensory neurons is unknown. Here, we show that in female mice (Mus musculus) basal GC receptor (Nr3c1, also known as GR) expression in dorsal root ganglion (DRG) sensory neurons is 15-fold higher than in neurons in canonical stress-responsive brain regions (M. musculus). In response to stress or GCs, adult DRG neurite growth increases through mechanisms involving GR-dependent gene transcription. In vivo, prior exposure to an acute systemic stress increases peripheral nerve regeneration. These data have broad clinical implications and highlight the importance of stress and GCs as novel behavioral and circulating modifiers of neuronal plasticity.
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