期刊
CANCER LETTERS
卷 397, 期 -, 页码 111-119出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.03.032
关键词
miR-29b; Angiogenesis; Breast cancer; Akt3
类别
资金
- National Natural Science Research Program of China [31501036, 81502338, 31401161, 31271030, 81400531]
- Young Elite Scientist Sponsorship Program by CAST [2016 QNRC001]
- Natural Science Basic Research Plan in Shaanxi Province of China [2016JM8086]
The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to reactive resistance to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for cancer therapy. In the present study, we identified a microRNA (miR-29b) with the ability of simultaneously inhibiting angiogenesis and tumorigenesis. Ectopic expression of miR-29b inhibits HUVECs formed three-dimensional capillary-like tubular structures, tumor cell proliferation, migration and tumor formation. Systemic administration of miR-29b potently suppressed tumor vascularization and cancer cell activity in vivo, resulting in dramatic suppression of tumor growth without toxicity. Moreover, we demonstrated the role of miR-29b in anti-angiogenesis and anti-tumorigenesis is through targeting Akt3 and inducing VEGF and C-myc arrest in breast cancer cells. These findings indicate that this single miRNA could be used as an efficient anti-cancer therapeutic agent to address a critical challenge in cancer therapy. (C) 2017 Elsevier B.V. All rights reserved.
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