期刊
ONCOTARGET
卷 8, 期 30, 页码 50164-50173出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16816
关键词
blood glucose; liver cancer; meta-analysis; prospective studies
资金
- National Nature Science Foundation of China [81373105]
- Fourth Round of Three-year Action Plan on Public Health Discipline and Talent Program: Evidence-based Public Health and Health Economics [15GWZK0901]
The question of whether elevated blood glucose is a risk factor for liver cancer has been intensively studied, yet with inconsistent results. To explore the relationship between blood glucose concentration and risk of liver cancer, we conduct a meta-analysis of prospective studies. Literature search was comprehensively performed using database of PubMed, EMBASE and the Cochrane Library through October 2016. Random-effect models were used to combine the effect estimations. Eight articles containing ten studies with a total of 1975 liver cancer cases were included. The pooled RRs demonstrated that elevated fasting blood glucose was associated with increased risk of liver cancer ( combined RRs: 1.77; 95% CI: 1.46, 2.13) with mild heterogeneity (I-2 = 30.40%, P = 0.17). In sensitivity analysis, the pooled result remained significant ( combined RRs: 1.33; 95% CI: 1.12, 1.59; I-2 = 33.90%, P = 0.16) when we restricted blood glucose categories in the range of nondiabetic subjects. We also detected a J-shaped non-linear dose-response relationship between blood glucose concentration and risk of liver cancer. There is evidence that elevated blood glucose increases risk of liver cancer across the range of prediabetes and diabetes. Considering the rapidly increasing prevalence of prediabetes and diabetes, controlling blood glucose may lower the risk of liver cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据