期刊
TRENDS IN CANCER
卷 3, 期 7, 页码 506-528出版社
CELL PRESS
DOI: 10.1016/j.trecan.2017.05.003
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资金
- Norte Portugal Regional Programme (NORTE) under the PORTUGAL Partnership Agreement through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000029]
- FEDER (Fundo Europeu de Desenvolvimento Regional) funds through COMPETE-Operational Programme for Competitiveness and Internationalisation (POCI), Portugal
- FCT (Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, Tecnologia e Inovacao) [POCI-01-0145-FEDER-007274]
- FCT [SFRH/BPD/109794/2015]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/109794/2015] Funding Source: FCT
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP-RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions remains fragmented. We review here the evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer
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