期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 45, 期 7, 页码 1620-1632出版社
SPRINGER
DOI: 10.1007/s10439-017-1793-9
关键词
Artificial gametes; Assisted reproductive technologies; Embryo research; Gametogenesis; Infertility; Parenthood; Stem cells
资金
- Innovation by Science and Technology in Flanders (IWT) [150042]
In this review we aim to provide an overview of the most important ethical pros and cons of stem cell derived gametes (SCD-gametes), as a contribution to the debate about reproductive tissue engineering. Derivation of gametes from stem cells holds promising applications both for research and for clinical use in assisted reproduction. We explore the ethical issues connected to gametes derived from embryonic stem cells (both patient specific and non-patient specific) as well as those related to gametes derived from induced pluripotent stem cells. The technology of SCD-gametes raises moral concerns of how reproductive autonomy relates to issues of embryo destruction, safety, access, and applications beyond clinical infertility.
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