期刊
ONCOTARGET
卷 8, 期 47, 页码 82303-82313出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19398
关键词
prostate cancer; miR-493-5p; c-Met; CREB1; EGFR
资金
- Zhejiang Province Key Project of Science and Technology [2014C04008-2]
- National Natural Science Foundation of China [81372773, 81402096, 81472375]
miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of miR-493-5p expression pattern and its function in prostate cancer remains to be elucidated. Here, we illustrate that miR-493-5p is frequently downregulated in prostate cancer, at least partially due to altered DNA methylation. miR-493-5p functions as a tumor suppressor in prostate cancer cells. c-Met, CREB1 and EGFR are downstream target genes of miR-493-5p. miR-493-5p inhibits EMT via AKT/GSK-3 beta/Snail signaling in prostate cancer. Taken together, our study identified c-Met, CREB1, EGFR and miR-493-5p establish a regulatory loop in prostate cancer, which could prove useful in the development of effective and therapies against prostate cancer.
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