期刊
ONCOTARGET
卷 8, 期 47, 页码 82294-82302出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19393
关键词
regulatory networks; chemoradiotherapy-resistance; rectal cancer; miRNAs; c-Myc
资金
- Ministry of Education (Juan de la Cierva)
- University of Granada (Beca de Iniciacion y Colaboracion a la Investigacion)
- Junta de Andalucia [PI-0710-201]
- Ministry of Economy of Spain [TIN2013-41990-R-MINECO/AE1/FEDER, SAF2015-67919-R]
- Fundacion de la Asociacion Espanola de Coloproctologia
Administration of chemoradiation before tumor resection has revolutionized the management of locally advanced rectal cancer, but many patients have proven resistant to this preoperative therapy. Our group recently reported a negative correlation between c-Myc gene expression and this resistance. In the present study, integrated analysis of miRNA and mRNA expression profiles was conducted in 45 pretreatment rectal tumors in order to analyze the expressions of miRNAs and c-Myc and their relationship with clinicopathological factors and patient survival. Twelve miRNAs were found to be differentially expressed by responders and non-responders to the chemoradiation. Functional classification revealed an association between the differentially expressed miRNAs and c-Myc. Quantitative real-time PCR results showed that miRNA-148 and miRNA-375 levels were both significantly lower in responders than in non-responders. Notably, a significant negative correlation was found between miRNA-375 expression and c-Myc expression. According to these findings, miRNA-375 and its targeted c-Myc may be useful as a predictive biomarker of the response to neoadjuvant treatment in patients with locally advanced rectal cancer.
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