期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 61, 期 7, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00539-17
关键词
Bacillus subtilis; antiviral peptide; influenza virus; probiotics
资金
- National Academy of Medical Sciences of Ukraine
- Auburn University fund FOP [101002-139294-2050]
Among Bacillus bacteria, B. subtilis is the species that produces the most antimicrobial compounds. In this study, we analyzed the activity of probiotic strain B. subtilis 3 against the influenza virus. The antiviral effect of this strain has been demonstrated in vitro and in vivo. A new peptide, P18, produced by the probiotic strain was isolated, purified, chemically synthesized, and characterized. Cytotoxicity studies demonstrated no toxic effect of P18 on Madin-Darby canine kidney (MDCK) cells, even at the highest concentration tested (100 mu g/ml). Complete inhibition of the influenza virus in vitro was observed at concentrations of 12.5 to 100 mu g/ ml. The protective effect of P18 in mice was comparable to that of oseltamivir phosphate (Tamiflu). Further study will assess the potential of peptide P18 as an antiviral compound and as a promising candidate for the development of new antiviral vaccines.
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