期刊
ONCOTARGET
卷 8, 期 39, 页码 65717-65729出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.20084
关键词
resveratrol; caloric restriction; SIRT1; aging
资金
- China Postdoctoral Science Foundation [2016M601237]
- Natural Science Foundation [81373704, 30873292]
Resveratrol and caloric restriction (CR) are the powerful therapeutic options for anti-aging. Here, their comparative effect on longevity-associated gene silencing information regulator (SIRT1) were evaluated in vitro and in vivo. IMR-90 cells treated with 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) were applied to establish a cellular senescence model, and rats treated with D-galactose (D-gal) were used as an aging animal model. Resveratrol and CR exhibited similar anti-aging activities, evidenced by inhibiting senescence and apoptosis, and restoring cognitive impairment and oxidative damage. Moreover, they could up-regulate telomerase (TE) activity, increase expressions of SIRT1, forkhead box 3a (Foxo3a), active regulator of SIRT1 (AROS) and Hu antigen R (HuR), but decrease p53 and deleted in breast cancer 1 (DBC1) levels. However, 10 mu M resveratrol in vitro and the high dose group in vivo showed relatively stronger activities of anti-aging and stimulating SIRT1 level than CR. In conclusion, resveratrol and CR showed similar anti-aging activities on SIRT1 signaling, implicating the potential of resveratrol as a CR mimetic.
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