期刊
ONCOTARGET
卷 8, 期 50, 页码 87073-87085出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19692
关键词
case-control study; nasopharyngeal carcinoma; china
资金
- National Cancer Institute at the U.S, National Institutes of Health [R01 CA115873]
- Swedish Research Council [2015-02625, 2015-06268]
- New Century Excellent Talents in University [NCET-12-0654]
- National Basic Research Program of China [2011CB504300]
- Guangxi Natural Science Foundation [2013GXNSFGA 019002]
- Karolinska Institutet [2368/10-221]
- Karolinska Institutet (KID)
- Swedish Research Council [2015-02625, 2015-06268] Funding Source: Swedish Research Council
With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014. Preparatory activities prior to subject enrollment required approximately 18 months. We enrolled a total of 2554 NPC cases and 2648 controls. Among all identified cases, 83.8% participated. For the participating cases, the median time between diagnosis and interview was 2 days. Among all contacted controls, 82.7% participated. From the enrolled cases, we collected 2518 blood specimens (provided by 98.6% of eligible cases), 2350 saliva specimens (92.0%), 2514 hair specimens (98.4%), and 2507 toenail/fingernail specimens (98.2%). From the enrolled controls, we collected 2416 blood specimens (91.2%), 2505 saliva specimens (94.6%), 2517 hair specimens (95.1%), and 2514 toenail/ fingernail specimens (94.9%). We demonstrate that population-based epidemiologic research can successfully be conducted in southern China. The study protocols, databases, and biobank will serve as an extraordinarily valuable resource for testing future etiologic hypotheses.
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