期刊
ONCOTARGET
卷 8, 期 31, 页码 51986-51993出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17727
关键词
alternative splicing; breast cancer; spliceosome; variants
资金
- foundation for the 1022 first level of innovative talents of Zhejiang Cancer Hospital, China [2013102202]
- Key platform technological project of Zhejiang medical science and hygiene [2016ZDB003]
Alternative splicing (AS) is the process of combinatorial rearrangement of parts of exons, and/or parts of introns into mature RNA to result in a multitude of transcripts. AS is a biological process through which organisms produce as many protein variants as possible by a limited genetic resource. It plays an important role in growth and development of the organisms. Over the past few years, alternative splicing has been discovered to be critical for genesis and development of malignant tumors, including breast cancer. If the relationships between AS and breast cancer can be discussed more deeply, it will be helpful for better diagnosis, judging prognosis and intervening with breast cancer. In this paper, the relationships between AS and breast cancer are elaborated from different angles, in hope that this summary is beneficial for readers to understand the roles of AS and breast cancer.
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