期刊
ULTRASONOGRAPHY
卷 36, 期 3, 页码 171-184出版社
KOREAN SOC ULTRASOUND MEDICINE
DOI: 10.14366/usg.17021
关键词
Ultrasonography; Drug delivery systems; Cancer therapy; Genetic therapy; Microbubbles
资金
- NIH [R01 CA155289, R01 DK092509, R21 EB022298, 2T32 CA118681-11A1]
Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.
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