期刊
CHEMOSPHERE
卷 178, 期 -, 页码 449-457出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2017.03.075
关键词
Decabromodiphenyl ether; Nano-SiO2 particles; Bioconcentration; Teratogenic responses; Zebrafish embryos
资金
- National Science Council (NSC), Taiwan [NSC 101-2221-E009-067]
This study investigated the influence of nano-SiO2 particles (nSiO(2)) on the teratogenic responses of zebrafish embryos to decabromodiphenyl ether (BDE-209). Zebrafish embryos were exposed to BDE-209 in the absence and presence of nSiO(2) for 96 h post fertilization (hpf). Results showed that formation of nSiO(2)-BDE-209 associates promoted both extracellular and intracellular uptake of BDE-209 by zebrafish embryos, thereby increasing the bioconcentration of BDE-209 on the chorion surface and the embryos. Results also showed embryos delay hatching temporarily when co-exposure to BDE-209 and nSiO(2) at 60 hpf. Furthermore, there was heartbeat decline (28.3 beats/10s) and increase in irregular heartbeat (45.8%) in zebrafish larvae at 96 hpf, compared to the sole exposure to BDE-209 (32.7 beats/10s and 0%). Malformation in terms of spinal curvature (SC), pericardial edema (PE) and yolk sac edema (YSE) were observed on zebrafish larvae at 33.9, 23.4, and 18%, respectively. Overall, abnormal development of zebrafish was apparent when co-exposure to BDE-209 and nSiO(2). All relevant evidence considered, nSiO(2) could facilitate the transport of BDE-209 towards zebrafish embryos and negatively impact the development of zebrafish. (C) 2017 Elsevier Ltd. All rights reserved.
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