期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 98, 期 7, 页码 1283-1290出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2017.01.011
关键词
Gait disorders, neurologic; Parkinson disease; Rehabilitation; Transcranial direct current stimulation; Transcranial magnetic stimulation
资金
- Samsung Medical Center [CRO112051]
- National Research Foundation of Korea - Korean government (MSIP) [NRF-2014R1A2A1A01005128]
- National Research Foundation of Korea [2014R1A2A1A01005128] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective: To investigate the effect of dual-mode noninvasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson disease (PD) with freezing of gait (FOG). Design: Randomized, double-blind, controlled study. Setting: Outpatient rehabilitation clinics. Participants: Patients diagnosed as having PD with FOG (N=32). Interventions: Patients in the dual-mode group underwent 5 consecutive daily sessions of dual-mode NIBS with high-frequency rTMS and tDCS simultaneously, whereas patients in the rTMS group underwent high-frequency rTMS and sham tDCS. Main Outcome Measures: Assessments of FOG and motor, ambulatory, and cognitive function were performed 3 times: at baseline before NIBS, immediately after NIBS, and 1 week after cessation of NIBS. Results: Serious adverse effects were not observed in either group. Significant changes over time were observed in FOG, motor function, and ambulatory function in each group; however, there was no significant difference between the 2 groups. Executive function showed significant improvement after NIBS only in the dual-mode group. Conclusions: These results suggest the potential for dual-mode NIBS to modulate 2 different cortices simultaneously. Dual-mode NIBS might be considered a novel therapeutic approach for patients with PD. (C) 2017 by the American Congress of Rehabilitation Medicine
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据