期刊
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
卷 -, 期 27, 页码 4539-4545出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201500321
关键词
Nanoparticles; Peptides; Lanthanides; Medicinal chemistry; Imaging agents; Antitumor agents; Inhibitors
资金
- Hong Kong Research Grants Council [HKBU 203013]
- Hong Kong Baptist University [FRG1/14-15/015]
- Engineering and Physical Sciences Research Council (ESPRC)
- National Natural Science Foundation of China (NSFC) [21402167]
- Hong Kong Polytechnic University Durham University
- Polish Ministry of Science and Higher Education [N N507 499538]
- Engineering and Physical Sciences Research Council [1213303] Funding Source: researchfish
In this work, the shape effect of our same-sized hybrid nano-materials conjugated with two different Plk1-specific peptides had been investigated in terms of their photophysical properties, cellular uptake efficiencies, and selective inhibitory effects towards cancer and normal cells. The results clearly indicate that our spherical NaGdF4@SiO2-P-1 nanoparticles achieve the best performance for in vitro imaging, G2 phase cell arrest, and, hence, cell cycle inhibition.
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