期刊
NUTRIENTS
卷 9, 期 6, 页码 -出版社
MDPI AG
DOI: 10.3390/nu9060558
关键词
immune function; IFN-gamma; NK cell activity; probiotics
资金
- Bio-Synergy Research Project of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea [NRF-2012M3A9C4048762]
- Mid-Career Researcher Program of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea [NRF-2016R1A2B4011662]
- Cooperative Research Program for Agriculture Science & Technology Development (Project title: Development of functional material for immune enhancement using Weissella cibaria) Rural Development Administration, Republic of Korea [PJ010835]
The aim of this study was to investigate the impact of consuming dairy yogurt containing Lactobacillus paracasei ssp. paracasei (L. paracasei), Bifidobacterium animalis ssp. lactis (B. lactis) and heat-treated Lactobacillus plantarum (L. plantarum) on immune function. A randomized, open-label, placebo-controlled study was conducted on 200 nondiabetic subjects. Over a twelve-week period, the test group consumed dairy yogurt containing probiotics each day, whereas the placebo group consumed milk. Natural killer (NK) cell activity, interleukin (IL)-12 and immunoglobulin (Ig) G1 levels were significantly increased in the test group at twelve weeks compared to baseline. Additionally, the test group had significantly greater increases in serum NK cell activity and interferon (IFN)-gamma and IgG1 than placebo group. Daily consumption of dairy yogurt containing L. paracasei, B. lactis and heat-treated L. plantarum could be an effective option to improve immune function by enhancing NK cell function and IFN-gamma concentration.
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