期刊
NUTRIENTS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu9070653
关键词
sweet taste receptors; glucose sensing; nutrient sensing; leptin; hypothalamus
资金
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01-DK048419, P30-DK34933]
Sweet taste receptors are composed of a heterodimer of taste 1 receptor member 2 (T1R2) and taste 1 receptor member 3 (T1R3). Accumulating evidence shows that sweet taste receptors are ubiquitous throughout the body, including in the gastrointestinal tract as well as the hypothalamus. These sweet taste receptors are heavily involved in nutrient sensing, monitoring changes in energy stores, and triggering metabolic and behavioral responses to maintain energy balance. Not surprisingly, these pathways are heavily regulated by external and internal factors. Dysfunction in one or more of these pathways may be important in the pathogenesis of common diseases, such as obesity and type 2 diabetes mellitus.
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