期刊
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
卷 89, 期 1, 页码 577-589出版社
ACAD BRASILEIRA DE CIENCIAS
DOI: 10.1590/0001-3765201720160849
关键词
agro-industrial waste; antioxidant; cellular activities; cosmetics; enzyme inhibitions; fruit crop
资金
- office of the National Research Council of Thailand [56208000520, 59208040011]
Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O-2 scavenging (IC50 = 27.44 +/- 0.09) than those of litchi and rambutan (IC50 = 29.57 +/- 0.30 and 39.49 +/- 0.52 mu g/ml, respectively) and the quercetin standard (IC50 = 31.88 +/- 0.15 mu g/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88.29 +/- 0.25% and 79.46 +/- 0.92%, respectively) than tamarind (35.43 +/- 0.68% and 57.69 +/- 5.97%) or rambutan (31.08 +/- 0.38% and 53.99 +/- 6.18%). All extracts were safe to human skin fibroblasts and inhibit MMP-2, with litchi extract showing significantly (p < 0.01) enhanced inhibition over the standard, vitamin C (23.75 +/- 2.74% and 10.42 +/- 5.91% at 0.05 mg/ml, respectively). Extracts suppress melanin production in B16F10 melanoma cells through inhibition of tyrosinase and TRP-2, with litchi extract being the most potent, even more so than kojic acid (standard). These results highlight the potential for adding value to agro-industrial waste, as the basis for the sustainable production of innovative, safe, anti-aging cosmetic products.
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