期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 45, 期 9, 页码 2638-2649出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201545679
关键词
Antigen presentation/processing; Dendritic cells; Inflammation
类别
资金
- My First AIRC Grant Italian Cancer Association [MFAG 10684]
- Via Corridoni Milano Italy [7 20122]
- Italian Ministry of Health [GR2009, PON02_00186_2937475]
- NIH [R01 CA154656, F31CA192874]
- Pediatric Cancer Research Foundation
- Hyundai Hope-on-Wheels Hope Award
- Fondazione Umberto Veronesi
- Medical Research Council [13030]
- Medical Research Council [MC_PC_13030] Funding Source: researchfish
- MRC [MC_PC_13030] Funding Source: UKRI
Currently little is known as to how nutritionally derived compounds may affect dendritic cell (DC) maturation and potentially prevent inappropriate inflammatory responses that are characteristic of chronic inflammatory syndromes. Previous observations have demonstrated that two polyphenols quercetin and piperine delivered through reconstituted oil bodies (ROBs-QP) can influence DC maturation in response to LPS leading to a modulated inflammatory response. In the present study, we examined the molecular effects of ROBs-QP exposure on DC differentiation in mice and identified a unique molecular signature in response to LPS administration that potentially modulates DC maturation and activity in inflammatory conditions. Following LPS administration, ROBs-QP-exposed DCs expressed an altered molecular profile as compared with control DCs, including cytokine and chemokine production, chemokine receptor repertoire, and antigen presentation ability. In vivo ROBs-QP administration suppresses antigen-specific T-cell division in the draining lymph nodes resulting from a reduced ability to create stable immunological synapse. Our data demonstrate that polyphenols exposure can drive DCs toward a new anti-inflammatory molecular profile capable of dampening the inflammatory response, highlighting their potential as complementary nutritional approaches in the treatment of chronic inflammatory syndromes.
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