期刊
NEUROSCIENCE BULLETIN
卷 33, 期 5, 页码 510-514出版社
SPRINGER
DOI: 10.1007/s12264-017-0122-5
关键词
Parkinson's disease; FBXO2; FBXO6; FBXO12; FBXO41; Variant
资金
- National Key Research and Development Program of China [2016YFC1306604]
- National Basic Research Development Program of China [2014CB542400]
- National Natural Science Foundation of China [81271921, 81670216]
- Natural Science Foundation of Hunan Province, China [2015JJ4088, 2016JJ2166]
- Construction Fund for Key Subjects of the Third Xiangya Hospital of Central South University (Clinical Laboratory Diagnostics)
- New Xiangya Talent Project of the Third Xiangya Hospital of Central South University [20150301]
- Mittal Students' Innovative Project of Central South University [15MX50, 15MX53]
- National-level College Students' Innovative Training Plan Program of China [201610533288, 201610533290, 201610533292]
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene (FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs (FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants (rs9614, rs28924120, rs6442117, and rs61733550, respectively) were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in mainland China. Statistically significant differences in genotypic and allelic frequencies were detected only in the FBXO2 variant rs9614 (P = 0.001 and 0.023, respectively; odds ratio 0.819, 95% confidence interval 0.690-0.973) between patients and controls. These results suggest that the FBXO2 variant rs9614 C allele may decrease the PD risk in mainland Han Chinese and may be a biomarker for PD.
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