期刊
NEUROSCIENCE BULLETIN
卷 34, 期 1, 页码 200-207出版社
SPRINGER
DOI: 10.1007/s12264-017-0147-9
关键词
Neuron type; Single-cell technology; Somatosensory mechanism; Pain; Gene profiles
资金
- National Natural Science Foundation of China [31630033, 31130066, 31671094, 81300961]
- Chinese Academy of Sciences [XDB02010000, QYZDY-SSW-SMC007]
- Shanghai Science and Technology Committee [16JC1420500]
Different physical and chemical stimuli are detected by the peripheral sensory receptors of dorsal root ganglion (DRG) neurons, and the generated inputs are transmitted via afferent fibers into the central nervous system. The gene expression profiles of DRG neurons contribute to the generation, transmission, and regulation of various somatosensory signals. Recently, the single-cell transcriptomes, cell types, and functional annotations of somatosensory neurons have been studied. In this review, we introduce our classification of DRG neurons based on single-cell RNA-sequencing and functional analyses, and discuss the technical approaches. Moreover, studies on the molecular and cellular mechanisms underlying somatic sensations are discussed.
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