期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 24, 期 10, 页码 800-808出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3460
关键词
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资金
- European Union [701309]
- Marie Curie Actions (MSCA) [701309] Funding Source: Marie Curie Actions (MSCA)
The oxidative phosphorylation electron transport chain (OXPHOS-ETC) of the inner mitochondrial membrane is composed of five large protein complexes, named CI-CV. These complexes convert energy from the food we eat into ATP, a small molecule used to power a multitude of essential reactions throughout the cell. OXPHOS-ETC complexes are organized into supercomplexes (SCs) of defined stoichiometry: CI forms a supercomplex with CIII2 and CIV (SC I+ III2+ IV, known as the respirasome), as well as with CIII2 alone (SC I+ III2). CIII2 forms a supercomplex with CIV (SC III2+ IV) and CV forms dimers (CV2). Recent cryo-EM studies have revealed the structures of SC I+ III2+ IV and SC I+ III2. Furthermore, recent work has shed light on the assembly and function of the SCs. Here we review and compare these recent studies and discuss how they have advanced our understanding of mitochondrial electron transport.
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