期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 24, 期 12, 页码 1073-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3496
关键词
-
资金
- Ministry of Science and Technology of China [2013CB910402]
- National Natural Science Foundation of China [31330040, 31525007, 31500625]
- Chinese Academy of Sciences [XDB08010201]
- Outstanding Academic Leader Program of Science and Technology Commission of Shanghai Municipality [16XD1405000]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- National Institutes of Health, National Institute on Aging
During meiotic prophase, the meiosis-specific telomere-binding protein TERB1 regulates chromosome movement required for homologous pairing and recombination by interacting with the telomeric shelterin subunit TRF1. Here, we report the crystal structure of the TRF1-binding motif of human TERB1 in complex with the TRFH domain of TRF1. Notably, specific disruption of the TERB1-TRF1 interaction by a point mutation in the mouse Terb1 gene results in infertility only in males. We find that this mutation causes an arrest in the zygotene-early pachytene stage and mild telomere abnormalities of autosomes but unpaired X and Y chromosomes in pachytene, leading to massive spermatocyte apoptosis. We propose that the loss of telomere structure mediated by the TERB1-TRF1 interaction significantly affects homologous pairing of the telomere-adjacent pseudoautosomal region (PAR) of the X and Y chromosomes in mouse spermatocytes. Our findings uncover a specific mechanism of telomeres that surmounts the unique challenges of mammalian X-Y pairing in meiosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据