期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 24, 期 3, 页码 243-+出版社
NATURE PORTFOLIO
DOI: 10.1038/nsmb.3367
关键词
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资金
- European Research Council Advanced [339778]
- Cancer Research UK [C14303/A17197, C9681/A18618]
- [099232/z/12/z]
- Cancer Research UK [18618] Funding Source: researchfish
- European Research Council (ERC) [339778] Funding Source: European Research Council (ERC)
Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3' untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilization of the G4 motif of a human-specific LINE-1 element by small-molecule ligands stimulates retrotransposition.
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