期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 24, 期 10, 页码 791-799出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3463
关键词
-
资金
- UK Medical Research Council [MC_U105184330]
- European Research Council [693087-SPLICE3D]
- EMBO
- Marie Sklodowska-Curie fellowships
- MRC [MC_U105184330] Funding Source: UKRI
- Medical Research Council [MC_U105184330] Funding Source: researchfish
The spliceosome excises introns from pre-messenger RNAs using an RNA-based active site that is cradled by a dynamic protein scaffold. A recent revolution in cryo-electron microscopy (cryo-EM) has led to near-atomic-resolution structures of key spliceosome complexes that provide insight into the mechanism of activation, splice site positioning, catalysis, protein rearrangements and ATPase-mediated dynamics of the active site. The cryo-EM structures rationalize decades of observations from genetic and biochemical studies and provide a molecular framework for future functional studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据