期刊
ANALYTICAL BIOCHEMISTRY
卷 529, 期 -, 页码 171-178出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2016.08.026
关键词
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资金
- NIH [NS041262, NS057560, NS070839, R24 MH106049, R24 MH106049-S1, P30 NS076408, P41 EB015894, S10 RR026783]
- W.M. Keck Foundation
In the last decade, in vivo oxygen-17 (O-17) MRS has evolved into a promising MR technique for non-invasively studying oxygen metabolism and perfusion in aerobic organs with the capability of imaging the regional metabolic rate of oxygen and its changes. In this chapter, we will briefly review the methodology of the in vivo O-17 MRS technique and its recent development and applications; we will also discuss the advantages of the high/ultrahigh magnetic field for O-17 MR detection, as well as the challenges and potential of this unique MRS method for biomedical research of oxygen metabolism, mitochondrial function and tissue energetics in health and disease. (C) 2016 Elsevier Inc. All rights reserved.
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