期刊
ANALYTICAL BIOCHEMISTRY
卷 529, 期 -, 页码 193-215出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2017.01.018
关键词
Phosphorus magnetic resonance; spectroscopy; Energy metabolism; Skeletal muscle; Liver; Exercise-recovery; Saturation transfer
资金
- Christian Doppler Society - Clinical Molecular MR Imaging (MOLIMA)
- OeNB Jubilaeumsfond [15363, 15455]
- Slovak Grant Agencies VEGA [2/0001/17]
- APVV [15-0029]
- Wellcome Trust and the Royal Society [098436/Z/12/Z]
- Wellcome Trust [098436/Z/12/Z] Funding Source: Wellcome Trust
In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (P-31-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of P-31-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry. This paper presents a methodological overview of the P-31-MR techniques that can be used for basic, physiological, or clinical research of human skeletal muscle and liver in vivo. Practical issues of P-31-MRS experiments and examples of potential applications are also provided. As signal localization is essential for liver P-31-MRS and is important for dynamic muscle examinations as well, typical localization strategies for P-31-MR are also described. (C) 2017 The Authors. Published by Elsevier Inc.
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