期刊
CELL AND TISSUE RESEARCH
卷 369, 期 1, 页码 119-126出版社
SPRINGER
DOI: 10.1007/s00441-017-2606-z
关键词
Kidney; Drosophila; Podocytes; Proximal tubules; Renal genetics
类别
资金
- Fondation Bettencourt-Schueller
Renal diseases are a growing health burden, and innovative models to study their pathomechanisms are greatly needed. Here, we highlight how the fruit fly Drosophila melanogaster can be used to model kidney diseases. We focus on the nephrocyte that has recently been shown to exhibit podocyte and proximal tubular cell features. These cells can be manipulated with precise genetic tools to dissect filtration and reabsorption mechanisms. Thus, they represent a novel and easy-to-use alternative in experimental nephrology.
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