期刊
CLINICAL IMMUNOLOGY
卷 180, 期 -, 页码 84-94出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.04.001
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资金
- National Psoriasis Foundation
Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6(+) CD4(+) TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3(+) CD4(+) T-EM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA(+) CD4(+) T-CM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CIA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4(+) T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis. (C) 2017 Elsevier Inc. All rights reserved.
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