期刊
CLINICAL IMMUNOLOGY
卷 180, 期 -, 页码 111-119出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.05.008
关键词
Respiratory tract infection; Elderly; B-cell activating factor; Specific anti-polysaccharide deficiency; Mannose binding lectin; Immunodeficiency; Late onset
类别
资金
- Baxter-ESID [BT11-0000411]
- (European Society for Immunodeficiencies) fellowship
- Deutsche Forschungsgemeinschaft [TRR130]
Elderly with late-onset recurrent respiratory tract infections (RRTI) often have specific anti-polysaccharide antibody deficiency (SPAD). We hypothesized that late-onset RRTI is caused by mild immunodeficiencies, such as SPAD, that remain hidden through adult life. We analyzed seventeen elderly RRTI patients and matched controls. We determined lymphocyte subsets, expression of BAFF receptors, serum immunoglobulins, complement pathways, Pneumovax-23 vaccination response and genetic variations in BAFFR and MBL2. Twelve patients (71%) and ten controls (59%) had SPAD. IgA was lower in patients than in controls, but other parameters did not differ. However, a high percentage of both patients (53%) and controls (65%) were MBL deficient, much more than in the general population. Often, MBL2 secretor genotypes did not match functional deficiency, suggesting that functional MBL deficiency can be an acquired condition. In conclusion, we found SPAD and MBL deficiency in many elderly, and conjecture that at least the latter arises with age. (C) 2017 Elsevier Inc. All rights reserved.
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